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Any such combination should only occur under the supervision of a specialist such as an endocrinologist or metabolic medicine physician who can monitor for both efficacy and safety outcomes

It is more dangerous with higher doses or prolonged usage

The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]