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Collectively, GGCT emerges as a pivotal metabolic orchestrator in HCC and PCa, functioning as a bidirectional switch that diverts Gln toward GSH biosynthesis for redox defense while enhancing Glc-fueled TCA anaplerosis to sustain cell proliferation

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Moreover, the present studies reveal that the overall conversion of orally ingested l-carnitine to TMAO is a complex multistep process requiring an initial gut microbial l-carnitineBB conversion, followed by a second BBTMA transformation