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Statistics The recorded data (1 min bins) and derived parameters, Vt/Ti and Response Area (cumulative percent changes from pre-values) were taken for statistical analyses

Dermatologically tested

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Conflicts of interest Dr Wambier has served as an adviser for Chemistry Rx, Daniel Alain, and Young Pharmaceuticals and as an investigator for Incyte, Eli Lilly, Pfizer, SunPharma, and UCB