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Some small preliminary studies, including a randomised controlled trial by Gualano and colleagues (2011), suggest that creatine combined with exercise may enhance glucose uptake into skeletal muscle, possibly through increased GLUT4 transporter expression

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Semaglutide, marketed as Ozempic, Wegovy, and Rybelsus, is an FDA-approved GLP-1 receptor agonist used for type 2 diabetes and chronic weight management