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Ye F, Mathur S, Liu M, Borst SE, Walter GA, Sweeney HL, Vandenborne K (2013) Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse

Primary cAMP/PKA Pathway The primary signaling pathway involves Gs-mediated activation of adenylyl cyclase, leading to rapid accumulation of cyclic adenosine monophosphate (cAMP) and subsequent activation of protein kinase A (PKA)