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There is no argument that the drugs are much more potent and faster acting than your bodies natural GLP-1 hormones

10.1053/j.gastro.2016.07.011 70 WuF.DuY.YangJ.ShaoB.MiZ.YaoY.et al (2022)

[2] [9] By activating GLP-1 receptors, retatrutide is thought to enhance insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite

GLP-1 is simply a much more powerful signal for beta cells than glucagon