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doi:10.1016/S0140-6736(21)01324-6 96

This is one of the underappreciated downstream benefits of GLP-1 treatment for this population

Icotrokinra (JNJ-77242113), which is currently in development to treat patients with various IMIDs, is the first targeted oral peptide designed to selectively inhibit interleukin (IL)-23 signaling by blocking the IL-23 receptor on human immune cells

Elevated fasting glucagon concentrations also corresponded to worsened cardiometabolic risk outcomes in another study by the same group, 33 underscoring its potential clinical utility as a predictive biomarker