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GLP-1 agonists also help to modulate chronic inflammation linked with obesity by suppressing proinflammatory cytokines such as TNF-, IL-6, and IL-1, improving endothelial function

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Patients should be advised to: Aim for 6-8 glasses of fluid daily (approximately 1.52 litres), as recommended by the NHS, unless on a fluid restriction Note: patients with heart failure, chronic kidney disease, or other conditions requiring fluid restriction should follow their clinician's specific guidance Increase fluid consumption during episodes of nausea, vomiting, or diarrhoea Monitor urine colour as a simple indicator of hydration status (pale yellow suggests adequate hydration) Ensuring adequate electrolyte intake through dietary sources is essential

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