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journal cancer 134 , 15171528, (2014)

Furthermore, the use of ABPP to profile proteomic states has largely been restricted to lysates 8,10 , where protein interactions and compartmentalization are disrupted, potentially obscuring PTM-regulated binding events or generating artifacts due to probing of non-native conditions

IGFBP-2 is highly expressed in the blood of lung tumors and patients with lung cancer and high levels of IGFBP-2 are associated with poor survival and metastasis in patients with lung cancer