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Furthermore, in appendiceal ligation and puncture-mediated sepsis, investigators found a decrease in GSH content and GPX4 expression and an accumulation of cardiac iron content and lipid peroxidation levels [94]

SLC38A1 exhibits upregulated expression in breast cancer [62], gastric cancer [63], CRC [64], lung cancer [65], hepatocellular carcinoma [66] and melanoma [67], displaying a strong correlation with enhanced proliferation

But those trials havent yet been completed for opioid use disorder specifically